NATIONAL AND STATE NURSING EXAM- MCQ _MG_00 123
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1. Arsenic poisoning causes.
a. Myelopathy
b. Radiculopathy
c. Mononeuritis multiplex.
d. Polyneuritis.
Answer: d. Polyneuritis.
Description:Arsenic is a toxic metal that can cause a variety of health problems, including polyneuritis. Polyneuritis is a condition that affects the peripheral nerves, which are the nerves that connect the brain and spinal cord to the rest of the body. Arsenic poisoning can cause a variety of symptoms, including: Pain and numbness in the hands and feet Weakness in the limbs Difficulty walking Difficulty with fine motor skills Fatigue Depression Anxiety In severe cases, arsenic poisoning can lead to death. The other options are not as likely to be caused by arsenic poisoning. Mononeuritis multiplex is a condition that affects multiple nerves, but it is not caused by arsenic poisoning. Myelopathy is a condition that affects the spinal cord, but it is not caused by arsenic poisoning. Radiculopathy is a condition that affects the nerve roots, but it is not caused by arsenic poisoning.
2. Increase in number of cells in a tissue is called:
a. Aplasia
b. Hyperplasia
c. Hypoplasia
d. Hypertrophy
Answer: b. Hyperplasia
Description:An increase in the number of cells in a tissue is called "Hyperplasia."
3. Hypertrophy is:
a. Uncontrolled multiplication
b. Increases in size of cells.
c. Spreading to other site.
d. Increase in number of cells.
Answer: b. Increases in size of cells.
Description:Hypertrophy is the enlargement of an organ or tissue due to an increase in the size of its cells. This is in contrast to hyperplasia, which is the increase in the number of cells in an organ or tissue. Hypertrophy can be caused by a number of factors, including: Increased workload Increased demand for hormones Increased production of growth factors Hypertrophy can be a normal physiological process, such as the increase in the size of the heart muscle in response to exercise. However, it can also be a pathological process, such as the increase in the size of the liver in response to chronic alcohol abuse. The other options are incorrect. Increase in number of cells is called hyperplasia. Uncontrolled multiplication is called neoplasia. Spreading to other sites is called metastasis.
4. Qualitative alteration of differentiation of cells is known as:
a. Anaplasia
b. Aplasia
c. Metaplasia
d. Hypoplasia.
Answer: a. Anaplasia
Description:Qualitative alteration of differentiation of cells is known as "Anaplasia.
5. Transformation of one type of differentiated cell type to another differentiated cell type is known as:
a. Anaplasia
b. Metastasis.
c. Hypoplasia
d. Aplasia
Answer: b. Metastasis.
Description:Metastasis is the spread of cancer cells from their original site to other parts of the body. This occurs when cancer cells break away from the primary tumor and travel through the bloodstream or lymphatic system to other organs. Once the cancer cells reach a new organ, they can start to grow and form tumors. This can lead to serious health problems, such as organ failure and death. The other options are incorrect. Anaplasia is the loss of differentiated cell characteristics, which is a feature of cancer cells. Hypertrophy is the enlargement of an organ or tissue due to an increase in the size of its cells. Poor differentiation is the lack of differentiation of cancer cells.
6. The most important characteristic of malignant tumor as compared to a benign tumor is:
a. Hypertrophy
b. Metaplasia
c. Poor differentiation
d. Hyperplasia
Answer: b. Metaplasia
Description:The most important characteristic of a malignant tumor compared to a benign tumor is "Poor differentiation." Poor differentiation refers to the lack of normal structure and organization of cells in malignant tumors, whereas benign tumors tend to be well-differentiated and resemble the normal tissue they originated from. This lack of differentiation in malignant tumors can make them more aggressive and invasive, leading to the potential to spread to other parts of the body (metastasis). Metaplasia (option b) refers to the transformation of one type of tissue into another type of tissue and is not specifically related to the comparison of benign and malignant tumors.
7. Energy deriving process that take place in cancer cell is:
a. Glycolysis.
b. Pentose phosphate pathway.
c. Krebs cycle.
d. HMP shut
Answer: a. Glycolysis.
Description:Glycolysis is a metabolic pathway that breaks down glucose into pyruvate, producing energy in the form of ATP. It is the main source of energy for cells, including cancer cells. Cancer cells often have high levels of glycolysis, even in the presence of oxygen. This is called Warburg effect. The Warburg effect is thought to be due to a number of factors, including: Increased expression of glycolytic enzymes Decreased expression of mitochondrial enzymes Increased reliance on glucose for energy The Warburg effect is a hallmark of cancer cells and is thought to contribute to the growth and spread of cancer. The other options are incorrect. The Krebs cycle is a metabolic pathway that occurs in the mitochondria and produces energy in the form of ATP. HMP shunt is a metabolic pathway that produces NADPH, which is used for cell growth and repair. Pentose phosphate pathway is a metabolic pathway that produces pentose sugars, which are used for DNA synthesis.
8. Any among the following are cellular adaptations except:
a. Malformation
b. Amputation
c. Association
d. Mutation
Answer: a. Malformation
Description:Cellular adaptations are reversible changes that cells undergo in response to various stimuli or environmental changes to maintain homeostasis or cope with stress. The other options are not cellular adaptations: b. Mutation: Mutations are changes in the DNA sequence of a cell and can lead to altered protein production or function, but they are not considered cellular adaptations. c. Amputation: Amputation is the surgical removal of a body part and is not related to cellular adaptations. d. Association: Association does not describe a cellular adaptation but is a general term that can refer to various relationships or connections between different entities.
9. All among the following are cellular adaptations except:
a. Metaplasia.
b. Hypertrophy
c. Neoplasia
d. Hyperplasia
Answer: c. Neoplasia
Description:Neoplasia is not a cellular adaptation. It is a pathological process that involves the uncontrolled growth of cells. The other options, hypertrophy, hyperplasia, and metaplasia, are all cellular adaptations. Hypertrophy is the enlargement of an organ or tissue due to an increase in the size of its cells. Hyperplasia is the increase in the number of cells in an organ or tissue. Metaplasia is the transformation of one type of differentiated cell type to another differentiated cell type. These cellular adaptations are usually reversible and can be caused by a number of factors, such as increased workload, increased demand for hormones, or increased production of growth factors. Neoplasia, on the other hand, is a progressive and irreversible process that can lead to cancer.
10. Difference between benign and malignant neoplasm is:
a. Metastasis
b. None of the above.
c. Both a and b
d. Extent of tissue invasiveness
Answer: c. Both a and b
Description:a. Extent of tissue invasiveness: Benign neoplasms tend to grow locally and do not invade surrounding tissues. They are usually well-defined and do not spread to distant parts of the body. b. Metastasis: Malignant neoplasms have the ability to invade nearby tissues and spread to distant organs or tissues through the bloodstream or lymphatic system, leading to the formation of secondary tumors (metastases).
11. Which is not cancer?
a. Glaucoma
b. Sarcoma
c. Leukemia
d. Carcinoma
Answer: a. Glaucoma
Description:Glaucoma is an eye disease that damages the optic nerve, which is the nerve that carries images from the eye to the brain. It is not a type of cancer. The other options, leukemia, carcinoma, and sarcoma, are all types of cancer. Leukemia is a cancer of the blood cells. Carcinoma is a cancer of the epithelial cells, which are the cells that line the inside and outside of the body. Sarcoma is a cancer of the connective tissues, such as bone, muscle, and cartilage.
12. Absence of differentiation among the cell is known as:
a. Anaplasia
b. Mutation
c. Hypertrophy
d. Metaplasia
Answer: a. Anaplasia
Description:The absence of differentiation among cells is known as "Anaplasia." Anaplasia is a characteristic feature of malignant (cancerous) tumors, where the cells lose their normal structure and organization and become more undifferentiated and primitive in appearance. This lack of differentiation is one of the factors that make malignant tumors more aggressive and capable of invading surrounding tissues and spreading to other parts of the body.
13. Malignant tumor of fibrous tissues is:
a. Myoma
b. Lymphoma
c. Primitive cell tumor
d. Fibrosarcoma
Answer: d. Fibrosarcoma
Description:The answer is d. Fibrosarcoma. A fibrosarcoma is a malignant tumor of the fibrous tissues, which are the tissues that connect, support, and protect other tissues and organs in the body. Fibrosarcomas can occur in any part of the body, but they are most common in the arms, legs, and chest. Fibrous tissues are made up of fibroblasts, which are cells that produce collagen. Collagen is a protein that gives tissues their strength and flexibility. Fibrosarcomas are characterized by the uncontrolled growth of fibroblasts. Fibrous tumors are typically painless and slow-growing. However, they can sometimes grow rapidly and become painful. If a fibrosarcoma is suspected, a biopsy will be performed to confirm the diagnosis. Treatment for fibrosarcomas typically involves surgery to remove the tumor. Radiation therapy and chemotherapy may also be used in some cases. The other options are incorrect. Primitive cell tumor is a type of cancer that is made up of undifferentiated cells. Myoma is a benign tumor of the smooth muscle tissue. Lymphoma is a cancer of the lymphatic system.
14. Which of the following is not a typical difference factor between benign and malignant tumors?
a. Encapsulation
b. Cell differentiation
c. Growth rate
d. Size of the tumor.
Answer: d. Size of the tumor.
Description:Size of the tumor is not a typical difference factor, whereas characteristics such as growth rate, encapsulation, cell differentiation, morphology of cells and treatment differs.
15. Major difference between benign and malignant neoplasms is:
c. Complicity of diagnosis
a. Rate of hyperplasia
b. Incidence rate.
d. Characteristics of tissue invasiveness.
Answer: d. Characteristics of tissue invasiveness.
Description:Benign neoplasms do not invade surrounding tissues, while malignant neoplasms do. This means that benign neoplasms can be removed surgically without spreading to other parts of the body, while malignant neoplasms can spread and form new tumors. Other differences between benign and malignant neoplasms include: Growth rate: Benign neoplasms typically grow slowly, while malignant neoplasms can grow rapidly. Metastasis: Benign neoplasms do not metastasize, while malignant neoplasms can metastasize to other parts of the body. Cellular characteristics: Benign neoplasms are typically well-differentiated, meaning that they resemble the cells of the tissue from which they arose. Malignant neoplasms are typically poorly differentiated, meaning that they do not resemble the cells of the tissue from which they arose. The other options are incorrect. The rate of hyperplasia, incidence rate, and complexity of diagnosis are not major differences between benign and malignant neoplasms.
16. Spread of malignant cells from one part to other part of the body is known as:
c. Lymphoma
a. Primitive cell tumor
b. Myoma
d. Lipoma
Answer: d. Lipoma
Description:a. Primitive cell tumor: This is not a commonly used medical term. It is unclear what it refers to. b. Myoma: A myoma is a benign tumor that arises from smooth muscle cells, usually found in the uterus. It is not related to the spread of malignant cells. c. Lymphoma: Lymphoma is a type of cancer that originates in the lymphatic system, but it does not specifically refer to the spread of malignant cells. d. Lipoma: Lipoma is a benign tumor composed of fat cells and does not relate to the spread of malignant cells.
17. Spread of malignant cells form one part to other part of the body is known as:
a. Invasion
b. seeding
c. Metastasis
d. Spreading
Answer: c. Metastasis
Description:Metastasis is the spread of cancer cells from their original location to other parts of the body. This occurs when cancer cells break away from the primary tumor and travel through the bloodstream or lymphatic system to other organs. Once the cancer cells reach a new organ, they can start to grow and form tumors. This can lead to serious health problems, such as organ failure and death. The other options are incorrect. Invasion is the penetration of cancer cells into surrounding tissues. Spreading is the movement of cancer cells from one part of the body to another. Seeding is the spread of cancer cells from a primary tumor to other parts of the body through the seeding of cancer cells into the bloodstream or lymphatic system.
18. In which phase of cell cycle is DNA replicated?
a. M phase.
b. S phase
c. C1 phase
d. G2 phase
Answer: b. S phase
Description:DNA replication occurs during the "S phase" (Synthesis phase) of the cell cycle. During this phase, the cell synthesizes a copy of its DNA, ensuring that each daughter cell receives a complete set of genetic information when the cell divides in the subsequent M (mitotic) phase. So, the correct answer is "b. S phase."
19. During metaphase of mitosis, chromosomes:
a. Break and disintegrate.
b. Move towards the poles
c. Line up at the equator
d. Undergo coiling
Answer: c. Line up at the equator
Description:During metaphase of mitosis, the chromosomes line up at the equator of the cell. This is the middle of the cell, and it is where the mitotic spindle will attach to the chromosomes. The other options are incorrect. During metaphase, the chromosomes do not undergo coiling, move towards the poles, or break and disintegrate.
20. UV rays commonly damage:
a. Pancreases
b. Liver
c. Heart
d. Skin
Answer: d. Skin
Description:UV rays commonly damage the skin. Ultraviolet (UV) radiation from the sun can cause various harmful effects on the skin, including sunburn, premature aging (photoaging), and an increased risk of skin cancer.
21. Identify tumor suppressor gene among the following:
a. RB
b. NFI
c. APC
d. All of these
Answer: d. All of these
Description:APC, NFI, and RB are all tumor suppressor genes. Tumor suppressor genes are genes that help to prevent cells from becoming cancerous. When these genes are mutated or lost, it can lead to the development of cancer. APC is a gene that helps to regulate cell growth and division. Mutations in the APC gene can lead to the development of colorectal cancer. NFI is a gene that helps to repair DNA damage. Mutations in the NFI gene can lead to the development of a variety of cancers, including breast cancer, lung cancer, and leukemia. RB is a gene that helps to control the cell cycle. Mutations in the RB gene can lead to the development of retinoblastoma, a type of eye cancer. Other tumor suppressor genes include: BRCA1 BRCA2 P53 TP53 VHL Tumor suppressor genes are important for maintaining the integrity of the genome and preventing cancer. When these genes are mutated or lost, it can lead to the development of cancer.
22. Which of the following statements regarding epithelial dysplasia is not true?
a. Cellular pleomorphism
b. Nuclear hyperchromatism
c. Enlarged nucleoli
d. Decreased normal and abnormal mitosis.
Answer: d. Decreased normal and abnormal mitosis.
Description:Epithelial dysplasia is a term used to describe abnormal changes in the appearance and growth pattern of epithelial cells, which can be a precursor to cancer. The other statements are true regarding epithelial dysplasia: a. Nuclear hyperchromatism: This refers to an increase in the staining intensity of the cell nuclei, which is a common feature of dysplastic cells. b. Enlarged nucleoli: Dysplastic cells often have enlarged and irregularly shaped nucleoli, which are small structures within the cell nucleus involved in protein synthesis. c. Cellular pleomorphism: Pleomorphism means variation in the size, shape, and appearance of cells. Dysplastic cells typically exhibit cellular pleomorphism, which is not seen in normal healthy cells.
23. All are the examples of malignant tumor; EXCEPT:
a. Fibrosarcoma
b. Lymphoma
c. Leiomyoma
d. Leukemia
Answer: c. Leiomyoma
Description:Leiomyoma is a benign tumor composed of smooth muscle cells and is not considered malignant. The other options are examples of malignant tumors: a. Leukemia: Leukemia is a cancer of the blood and bone marrow, involving abnormal white blood cells. b. Fibrosarcoma: Fibrosarcoma is a malignant tumor arising from fibrous connective tissue. d. Lymphoma: Lymphoma is a type of cancer that originates in the lymphatic system and can be either Hodgkin's or non-Hodgkin's lymphoma.
24. The tumor of the hyaline cartilage is called:
a. Osteochondroma
b. Chondrosarcoma
c. Enchondroma
d. Osteosarcoma
Answer: c. Enchondroma
Description:An enchondroma is a type of non-cancerous bone tumor that begins in cartilage. Osteochondroma is an overgrowth of cartilage and bone that happens at the end of the bone near the growth plate. Osteosarcoma (OS) or osteogenic sarcoma (OGS) is a cancerous tumor that arises from primitive transformed cells of mesenchymal origin which exhibits osteoblastic differentiation and produces malignant osteoid. Chondrosarcoma is a cancer composed of cells derived from transformed cells that produce cartilage.
25. The severe weight loss accompanied by progressive weakness, loss of appetite and anemia that is usually associated with advanced cancer is called:
a. Dysplasia
b. Cachexia.
c. Anaplasia
d. Carcinomatosis
Answer: b. Cachexia.
Description:Cachexia is loss of weight, muscle atrophy, fatigue, weakness and significant loss of appetite in some who is not actively trying to lose weight. Carcinomatosis is a condition in which cancer in widespread in the body. Anaplasia is a condition of cell with poor cellular differentiation. Dysplasia is an abnormality of development or epithelial anomaly of growth and differentiation.
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