NATIONAL AND STATE NURSING EXAM- MCQ _MG_00 204
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1. Drug-induced parkinsonism is treated by:
a. Anticholinergics
b. Anticholinesterases
c. Cholinergic drugs
d. Hydralazine
Answer: a. Anticholinergics
Description:Drug induced parkinsonism is treated with anticholinergic drugs. For example, trihexyphenidyl, benztropine, amantadine etc.
2. Imipramine is an antidepressant of………..group.
a. Tricyclic antidepressant (TCA)
b. Selective serotonin reuptake inhibitor (SSRI)
c. Monoamine oxidase inhibitor (MAOI)
d. Non-selective serotonin reuptake inhibitors.
Answer: a. Tricyclic antidepressant (TCA)
Description:Imipramine is a tricyclic antidepressant (TCA) of the dibenzoazepine group. Imipramine is mainly used in the treatment of major depression and enuresis (inability to control urination)
3. Dry mouth during antidepressant therapy is caused by blockade of:
a. Muscarinic acetylcholine receptors
b. Dopaminergic receptors
c. GABA receptors
d. Serotonergic receptors
Answer: a. Muscarinic acetylcholine receptors
Description:Dry mouth during antidepressant therapy is caused by the blockade of muscarinic acetylcholine receptors. These receptors play a role in saliva production, and when they are blocked by certain antidepressant medications, it can lead to reduced saliva production and the sensation of dryness in the mouth.
4. Anxiolytic drug with antidepressant action is:
a. Lorazepam
b. Diazepam
c. Alprazolam
d. Triazolam
Answer: c. Alprazolam
Description:Anxiolytic drugs with antidepressant action are drugs like alprazolam (option c). These medications not only help reduce anxiety (anxiolytic) but also have an additional benefit of improving mood and helping with depression (antidepressant).
5. Which of the following drug is an example of Tricyclic Antidepressant (TCA)?
a. Imipramine
b. Sertraline
c. Hydralazine
d. Fluoxetine.
Answer: a. Imipramine
Description:An example of a Tricyclic Antidepressant (TCA) is imipramine (option a). TCAs are a type of medication used to treat depression, and imipramine is one of the drugs in this category.
6. Which of the following antidepressants cause urine retention:
a. Imipramine
b. Fluoxetine.
c. Dothiepin
d. Risperidone
Answer: a. Imipramine
Description:Imipramine, which is a tricyclic antidepressant, can cause urine retention as one of its side effects.
7. Anti-depressant drug that can safely be used in children is:
a. Imipramine
b. Fluoxetine.
c. Dothiepin
d. Chlorpromazine.
Answer: b. Fluoxetine.
Description:Fluoxetine is one of the few antidepressant medications that can be safely used in children and adolescents, under the guidance and supervision of a qualified healthcare professional. Imipramine (option a), on the other hand, is generally not recommended for use in children due to potential safety concerns.
8. Which of the following excreted in saliva?
a. Tetracycline
b. Ampicillin
c. Lithium
d. Chloramphenicol
Answer: c. Lithium
Description:Lithium is excreted in saliva. Saliva is one of the routes through which the body eliminates this medication.
9. Frequent serum level monitoring is required when patient is on:
a. Amitriptyline
b. Haloperidol
c. Lithium
d. Lorazepam
Answer: c. Lithium
Description:Frequent serum level monitoring is required when a patient is on lithium therapy. Lithium levels in the blood need to be carefully monitored because the therapeutic range is relatively narrow, and levels that are too high or too low can lead to adverse effects or reduced effectiveness of the medication.
10. Lithium is used in a pregnant woman. Which of the following congenital anomaly occurs is fetus?
a. Tetralogy of Fallot
b. Tricuspid atresia
c. Ebsteins anomaly
d. Pulmonary stenosis.
Answer: c. Ebsteins anomaly
Description:Lithium use during pregnancy has been associated with an increased risk of Ebstein's anomaly, a congenital heart defect. It's important for pregnant women to carefully consider the potential risks and benefits of taking lithium, and they should discuss their treatment options with their healthcare provider to make informed decisions regarding their mental health treatment during pregnancy.
11. Long term use of lithium causes:
a. Peripheral neuropathy
b. Hypothyroidism
c. Anemia
d. Jaundice
Answer: b. Hypothyroidism
Description:Long-term use of lithium is associated with an increased risk of hypothyroidism, a condition where the thyroid gland does not produce enough thyroid hormone. It's important for individuals taking lithium to undergo regular thyroid function monitoring to detect and manage any thyroid-related issues that may arise.
12. The therapeutic serum level of lithium is;
a. 0.3-0.6 mEq/L
b. 0.6-1.2 mEq/L
c. 1.2-1.8 mEq/L
d. 1.8-2.5 mEq/L
Answer: b. 0.6-1.2 mEq/L
Description:The therapeutic serum level of lithium is typically in the range of 0.6-1.2 milliequivalents per liter (mEq/L). This range is considered optimal for managing bipolar disorder and other conditions for which lithium is prescribed. However, the exact target level may vary depending on the individual and their specific circumstances, so it should be determined by a healthcare professional. Monitoring lithium levels is crucial to ensure the medication's effectiveness and safety.
13. Treatment of choice of bipolar mood disorders:
a. Fluoxenline
b. Imipramine
c. Lithium
d. Chlorpromazine
Answer: c. Lithium
Description:Lithium is often considered the treatment of choice for bipolar mood disorders, such as bipolar disorder and bipolar depression. It is a mood stabilizer that helps manage manic and depressive episodes in bipolar patients. The other options listed are not typically considered first-line treatments for bipolar disorder.
14. Lithium monitoring is done because of:
a. Low therapeutic efficacy
b. Very low therapeutic index
c. Adverse effects
d. Long half life.
Answer: b. Very low therapeutic index
Description:Lithium monitoring is done because it has a very low therapeutic index, meaning that the difference between a therapeutic dose and a toxic dose is relatively small. Therefore, it is important to carefully monitor lithium levels in the blood to ensure that patients are within the therapeutic range and avoid toxicity. Monitoring helps to balance the benefits of lithium in managing mood disorders with the risk of toxicity.
15. Therapeutic drug monitoring must be done for:
a. Penicillin
b. Lithium
c. Erythromycin
d. Lignocaine e
Answer: b. Lithium
Description:Therapeutic drug monitoring is commonly performed for lithium to ensure that the medication is within the therapeutic range and to prevent potential toxicity due to its narrow therapeutic index. Monitoring helps to optimize the effectiveness and safety of lithium treatment for mood disorders. While monitoring may be done for other medications in specific situations, it is most commonly associated with lithium.
16. Lithium therapy during pregnancy increases the chance of…………..in fetus:
a. Anencephaly
b. Neural tube defects
c. Defects in extremities
d. Cardiac malformations
Answer: d. Cardiac malformations
Description:Women treated with lithium during pregnancy at risk for Ebstein’s anomaly of the fetus. Ebstein’s anomaly is congenital malformation of the heart.
17. Drug of choice for prophylaxis of mania is:
a. Lithium
b. Haloperidol
c. Clozapine
d. Carbamazepine
Answer: a. Lithium
Description:Lithium is often considered the drug of choice for the prophylaxis (prevention) of manic episodes in bipolar disorder. It is a well-established mood stabilizer and is effective in reducing the frequency and severity of manic episodes.
18. Drug which causes hypothyroidism is:
a. Carbamazepine
b. Lithium
c. Sulphur
d. Methotrexate
Answer: b. Lithium
Description:Lithium is known to be associated with the development of hypothyroidism as a potential side effect. Regular thyroid function monitoring is recommended for individuals taking lithium to detect and manage hypothyroidism when it occurs.
19. Disulfiram, an Antabuse drug used in Alcohol depends syndrome acts by deactivating:
a. Acetaldehyde dehydrogenase
b. GABA
c. Acetylcholine
d. Choline-esterase.
Answer: a. Acetaldehyde dehydrogenase
Description:Disulfiram, marketed under the brand name Antabuse, works by inhibiting the enzyme acetaldehyde dehydrogenase. This enzyme is responsible for breaking down acetaldehyde, a toxic substance that is produced when alcohol is metabolized in the body. By inhibiting acetaldehyde dehydrogenase, disulfiram causes an accumulation of acetaldehyde, leading to unpleasant symptoms when alcohol is consumed, which acts as a deterrent to drinking in individuals with alcohol dependence syndrome.
20. A patient with substance use disorder presents with increased lacrimation, abdominal cramping agitation, and rhinorrhea. These symptoms indicate withdrawal of:
a. Opioid
b. Cocaine
c. Nicotine
d. Marijuana
Answer: a. Opioid
Description:Withdrawal symptoms of opioid includes sweating, lacrimation, diarrhea, abdominal cramping, muscle aches, yawning diarrhea, fever, agitation, goose bumps, and insomnia.
21. Disulfiram (Antabuse) is used in:
a. Withdrawal phase of Alcohol Dependence syndrome
b. Maintenance phase of Alcohol Dependence syndrome
c. Treatment of alcohol intoxication
d. All of the above.
Answer: a. Withdrawal phase of Alcohol Dependence syndrome
Description:Disulfiram (Antabuse) is typically used in the withdrawal phase of Alcohol Dependence syndrome to deter individuals from drinking alcohol. It creates unpleasant effects when alcohol is consumed, serving as a deterrent to drinking during the early stages of recovery from alcohol dependence. It is not used in the maintenance phase or for the treatment of alcohol intoxication.
22. Which among the following drugs is used in the treatment of alcohol dependence?
a. Disulfiram
b. Lithium
c. Carbamazepine
d. Verapamil
Answer: b. Lithium
Description:The drug most commonly used in the treatment of alcohol dependence is not listed. The options provided include some medications used in various contexts but are not the primary medications for alcohol dependence treatment. Common medications for alcohol dependence treatment include: Disulfiram (Antabuse) Naltrexone (ReVia, Vivitrol) Acamprosate (Campral) These drugs work in different ways to help individuals with alcohol dependence reduce their alcohol consumption or maintain abstinence. Lithium and carbamazepine, which are listed in the options, are not typically used as first-line treatments for alcohol dependence.
23. The drug which is used to create aversion in Alcohol Dependence:
a. Apomorphine
b. Propranolol
c. Diazepam
d. Disulfiram
Answer: a. Apomorphine
Description:Apomorphine is a medication that can be used to create aversion in individuals with alcohol dependence. It works by inducing nausea and vomiting when alcohol is consumed, which can deter individuals from drinking alcohol. Disulfiram (option d) is another drug used for aversion therapy in alcohol dependence, but in this case, it creates aversion by causing unpleasant symptoms when alcohol is consumed.
24. Drug used in uncomplicated alcohol withdrawal:
a. Diazepam
b. Clonidine
c. Propranolol
d. Methadone
Answer: a. Diazepam
Description:Diazepam is commonly used in the treatment of uncomplicated alcohol withdrawal to manage symptoms such as anxiety, agitation, and tremors. It belongs to a class of drugs called benzodiazepines, which help alleviate the symptoms of alcohol withdrawal and prevent more severe withdrawal complications, such as seizures and delirium tremens. Clonidine (option b) and propranolol (option c) may be used in certain situations to manage specific symptoms, but they are not typically the first-line treatment for uncomplicated alcohol withdrawal. Methadone (option d) is used for opioid withdrawal, not alcohol withdrawal.
25. Disulfiram inhibits:
a. Alcohol dehydrogenase
b. Aldehyde dehydrogenase
c. G6PD
d. Acetate dehydrogenase.
Answer: b. Aldehyde dehydrogenase
Description:Disulfiram inhibits aldehyde dehydrogenase, an enzyme responsible for breaking down acetaldehyde, a toxic byproduct of alcohol metabolism. By inhibiting this enzyme, disulfiram leads to an accumulation of acetaldehyde in the body when alcohol is consumed, resulting in unpleasant symptoms as a deterrent to drinking.
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